With the progress of information science and technology, the way of archives management is also constantly iterative update, now into the information age, university personnel file management mode also gradually to the direction of information management, this for colleges and universities, it is to improve the efficiency of personnel file management work, bring efficiency of university personnel management at the same time, to call read file convenience is also improved. Today, this paper takes the information management of university personnel files as the theme, and puts forward the effective practice of the information management of personnel files in colleges and universities, hoping to be helpful to the personnel file management of universities.